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Cardiovascular medications - cardiac glycosides

Medications:

  • Digoxin
    • Lanoxicaps
    • Lanoxin
    • Digibind

Depletions:

Magnesium

Magnesium deficiency affects calcium and vitamin D levels in the body and may be associated with muscle cramps, irregular heartbeat, insomnia, high blood pressure, diabetes, and osteoporosis (bone loss).

Vitamin B1 (Thiamine)

Symptoms of depleted levels of thiamine include weakness, fatigue, anorexia, constipation, memory loss, confusion, and depression. Deficiency may lead to beriberi, a condition characterized by inflammation of nerves, heart irregularities, and fluid retention.

Editorial Note:

The selected depletions information presented here identifies some of the nutrients that may be depleted by certain medications. The signs and symptoms associated with nutrient deficiency may also indicate conditions other than nutrient deficiency. If you are experiencing any of the signs or symptoms mentioned, it does not necessarily mean that you are nutrient deficient. Nutrient depletion depends upon a number of factors, including your medical history, diet, and lifestyle as well as the length of time you have been taking the medication. Please consult your health care provider; he or she can best assess and address your individual health care needs, and determine if you are at risk for nutrient depletions from these medications as well as others not listed here.

  • Reviewed last on: 12/24/2007
  • Steven D. Ehrlich, NMD, private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed HealthCare Network. Also reviewed by Ernest B. Hawkins, MS, BSPharm, RPh, Health Education Resources.

Supporting Research

Cashman K, Flynn A. Optimal nutrition: calcium, magnesium and phosphorus. Proc Nutr Soc. 1999;58:477-487.

Fox C, Ramsoomair D, Carter C. Magnesium: its proven and potential clinical significance.South Med J. 2001;94(12):1195-201.

Hordyjewska A, Pasternak K. Magnesium role in cardiovascular diseases. Ann Univ Mariae Curie Sklodowska [Med]. 2004;59(2):108-13.

Lee BY, Yanamandra K, Bocchini JA Jr. Thiamin deficiency: a possible major cause of some tumors? (review). Oncol Rep. 2005;14(6):1589-92.

Nielsen FH, Milne DB, Klevay LM, Gallagher S, Johnson L. Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women. J Am Coll Nutr. 2007;26(2):121-32.

Rodríguez-Morán M, Guerrero-Romero F. Serum magnesium and C-reactive protein levels. Arch Dis Child. 2007; [Epub ahead of print].

Zangen A, Botzer D, Zangen R, Shainberg A. Furosemide and digoxin inhibit thiamine uptake in cardiac cells. Eur J Pharmacol. 1998;61(1):151-155.

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